Seiji Ogawa
Seiji Ogawa (小川 誠二 ''Ogawa Seiji'', born January 19, 1934) is a Japanese biophysicist and neuroscientist known for discovering the technique that underlies
Functional Magnetic Resonance Imaging (fMRI). He is regarded as the father of modern functional
brain imaging. He determined that the changes in blood oxygen levels cause its
magnetic resonance imaging properties to change, allowing a map of blood, and hence, functional, activity in the brain to be created. This map reflected which
neurons of the brain responded with electrochemical signals to mental processes. He was the first scientist who demonstrated that the functional brain imaging is dependent on the oxygenation status of the blood, the BOLD effect. The technique was therefore called
blood oxygenation level-dependent or BOLD contrast. Functional MRI (fMRI) has been used to map the visual, auditory, and sensory regions and moving toward higher brain functions such as cognitive functions in the brain.
In 2020, Ogawa was appointed as
Osaka University Distinguished Honorary Professor. He is the second scholar to receive this title after
Nobel Prize winner
Yoichiro Nambu.
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