Genetic and Epigenetic Regulations of Tumor Progression and Metastasis

• Outros Autores: Smolkova, Bozena (Editor), Earl, Julie (Editor), Kataki, Agapi (Editor)
• Formato: Recurso Electrónico Capítulo de Livro
• Idioma: inglês
• Publicado em: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Assuntos: Medicine; Oncology; prostate cancer; metastasis; epithelial-to-mesenchymal transition (EMT); partial-EMT (p-EMT); Zeb1; DNA methylation; 5-azacytidine; lung adenocarcinoma; brain metastasis; omics data analysis; CDKN2A; p16; invasive ductal breast cancer; CDH1 gene; EMT genes; miRNA and mRNA expression; E-cadherin; HTR2B; STAT proteins; uveal melanoma; promoter; gene transcription; PDAC; inflammation; hypoxia; epithelial-to-mesenchymal transition; cancer proliferation; hepatocellular carcinoma; engineered exosomes; diagnostic biomarker; cancer therapy; angiogenesis; pericytes; adipose tissue; cell adhesion; endothelial cells; breast cancer; metastatic cascade; intra-tumor heterogeneity; mutational profile; adaptive responses; autophagy; tumor mutational burden; tumor microenvironment; waterpipe smoke; lung cancer; n/a; CYSLTR1; CYSLTR2; methylation; prognosis; colorectal cancer; EMT
• Acesso em linha: DOAB: download the publication; DOAB: description of the publication

Resumo

Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease.

Descrição Física

1 electronic resource (208 p.)

ISBN

books978-3-0365-7184-3
9783036571850
9783036571843

Acesso

Open Access