Genetic and Epigenetic Regulations of Tumor Progression and Metastasis
Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therap...
Saved in:
Other Authors: | , , |
---|---|
Format: | Electronic Book Chapter |
Language: | English |
Published: |
Basel
MDPI - Multidisciplinary Digital Publishing Institute
2023
|
Subjects: | |
Online Access: | DOAB: download the publication DOAB: description of the publication |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
LEADER | 00000naaaa2200000uu 4500 | ||
---|---|---|---|
001 | doab_20_500_12854_100008 | ||
005 | 20230511 | ||
003 | oapen | ||
006 | m o d | ||
007 | cr|mn|---annan | ||
008 | 20230511s2023 xx |||||o ||| 0|eng d | ||
020 | |a books978-3-0365-7184-3 | ||
020 | |a 9783036571850 | ||
020 | |a 9783036571843 | ||
040 | |a oapen |c oapen | ||
024 | 7 | |a 10.3390/books978-3-0365-7184-3 |c doi | |
041 | 0 | |a eng | |
042 | |a dc | ||
072 | 7 | |a M |2 bicssc | |
072 | 7 | |a MJCL |2 bicssc | |
100 | 1 | |a Smolkova, Bozena |4 edt | |
700 | 1 | |a Earl, Julie |4 edt | |
700 | 1 | |a Kataki, Agapi |4 edt | |
700 | 1 | |a Smolkova, Bozena |4 oth | |
700 | 1 | |a Earl, Julie |4 oth | |
700 | 1 | |a Kataki, Agapi |4 oth | |
245 | 1 | 0 | |a Genetic and Epigenetic Regulations of Tumor Progression and Metastasis |
260 | |a Basel |b MDPI - Multidisciplinary Digital Publishing Institute |c 2023 | ||
300 | |a 1 electronic resource (208 p.) | ||
336 | |a text |b txt |2 rdacontent | ||
337 | |a computer |b c |2 rdamedia | ||
338 | |a online resource |b cr |2 rdacarrier | ||
506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
520 | |a Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
546 | |a English | ||
650 | 7 | |a Medicine |2 bicssc | |
650 | 7 | |a Oncology |2 bicssc | |
653 | |a prostate cancer | ||
653 | |a metastasis | ||
653 | |a epithelial-to-mesenchymal transition (EMT) | ||
653 | |a partial-EMT (p-EMT) | ||
653 | |a Zeb1 | ||
653 | |a DNA methylation | ||
653 | |a 5-azacytidine | ||
653 | |a lung adenocarcinoma | ||
653 | |a brain metastasis | ||
653 | |a omics data analysis | ||
653 | |a CDKN2A | ||
653 | |a p16 | ||
653 | |a invasive ductal breast cancer | ||
653 | |a CDH1 gene | ||
653 | |a EMT genes | ||
653 | |a miRNA and mRNA expression | ||
653 | |a E-cadherin | ||
653 | |a HTR2B | ||
653 | |a STAT proteins | ||
653 | |a uveal melanoma | ||
653 | |a promoter | ||
653 | |a gene transcription | ||
653 | |a PDAC | ||
653 | |a inflammation | ||
653 | |a hypoxia | ||
653 | |a epithelial-to-mesenchymal transition | ||
653 | |a cancer proliferation | ||
653 | |a hepatocellular carcinoma | ||
653 | |a engineered exosomes | ||
653 | |a diagnostic biomarker | ||
653 | |a cancer therapy | ||
653 | |a angiogenesis | ||
653 | |a pericytes | ||
653 | |a adipose tissue | ||
653 | |a cell adhesion | ||
653 | |a endothelial cells | ||
653 | |a breast cancer | ||
653 | |a metastatic cascade | ||
653 | |a intra-tumor heterogeneity | ||
653 | |a mutational profile | ||
653 | |a adaptive responses | ||
653 | |a autophagy | ||
653 | |a tumor mutational burden | ||
653 | |a tumor microenvironment | ||
653 | |a waterpipe smoke | ||
653 | |a lung cancer | ||
653 | |a n/a | ||
653 | |a CYSLTR1 | ||
653 | |a CYSLTR2 | ||
653 | |a methylation | ||
653 | |a prognosis | ||
653 | |a colorectal cancer | ||
653 | |a EMT | ||
856 | 4 | 0 | |a www.oapen.org |u https://mdpi.com/books/pdfview/book/7101 |7 0 |z DOAB: download the publication |
856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/100008 |7 0 |z DOAB: description of the publication |