Genetic and Epigenetic Regulations of Tumor Progression and Metastasis

• Weitere Verfasser: Smolkova, Bozena (Herausgegeben von), Earl, Julie (Herausgegeben von), Kataki, Agapi (Herausgegeben von)
• Format: Elektronisch Buchkapitel
• Sprache: Englisch
• Veröffentlicht: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Schlagworte: Medicine; Oncology; prostate cancer; metastasis; epithelial-to-mesenchymal transition (EMT); partial-EMT (p-EMT); Zeb1; DNA methylation; 5-azacytidine; lung adenocarcinoma; brain metastasis; omics data analysis; CDKN2A; p16; invasive ductal breast cancer; CDH1 gene; EMT genes; miRNA and mRNA expression; E-cadherin; HTR2B; STAT proteins; uveal melanoma; promoter; gene transcription; PDAC; inflammation; hypoxia; epithelial-to-mesenchymal transition; cancer proliferation; hepatocellular carcinoma; engineered exosomes; diagnostic biomarker; cancer therapy; angiogenesis; pericytes; adipose tissue; cell adhesion; endothelial cells; breast cancer; metastatic cascade; intra-tumor heterogeneity; mutational profile; adaptive responses; autophagy; tumor mutational burden; tumor microenvironment; waterpipe smoke; lung cancer; n/a; CYSLTR1; CYSLTR2; methylation; prognosis; colorectal cancer; EMT
• Online-Zugang: DOAB: download the publication; DOAB: description of the publication

Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therap...