Purinergic Signaling in Neuroinflammation

• Other Authors: Aminin, Dmitry (Editor), Illes, Peter (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; adenosine receptors; adipogenesis; osteogenesis; adipose tissue; bone marrow; obesity; neonatal seizures; development; ATP; purinergic signalling; P2X7 receptor; endometriosis; adenosine; P2Y; P2X; ectonucleotidases; pain; inflammation; endometrium; CD73; CD39; P2Y2 receptor; P2X4 receptor; canine; dog; DH82; macrophage; neuroinflammation; antinociception; cerebral ischemia; oxygen-glucose deprivation; A2B receptors; oligodendrocyte differentiation; demyelination; retina; purinergic modulation; glycinergic neurotransmission; microglia; neurodegeneration; glycine transporters; guanosine; stroke; neuroprotection; purinergic signaling; purinergic receptors; autoimmune disease; astroglia; G protein-coupled receptor 17 (GPR17); neurite outgrowth; montelukast; NG2; ex vivo organotypic brain slice co-culture; neurodegeneration and neuroregeneration; n/a; macrophages; P2X7R; pore formation; inflammasome activation; inflammatory diseases; gallic acid; visceral pain; depression; hippocampus; spinal cord; dorsal root ganglion
• Online Access: DOAB: download the publication; DOAB: description of the publication

It is currently apparent that extracellular ATP's physiological effect is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors and P2-purinoreceptors. Each of the subtypes is divided into a number of families. For instance, P2 receptors are divided into P2X and P2Y receptors according to the mechanism by which their effect is realized: P2Y are G-protein-coupled receptors, while P2X receptors are ligand-operated ion channels. P2X receptors are important molecular therapeutic targets, the malfunctioning of which leads to severe complications in the physiology of humans and animals and causes dangerous diseases. The search for compounds that can modulate the function of purinergic receptors can lead to the creation of new drugs that are effective in central and peripheral nervous system and immune system disease treatment, including neuroinflammation, hypoxia/ischemia, epilepsy and neuropathic pain. In this Special Issue, we wish to offer a platform for high-quality publications on the latest advances in the identification of P2X/Y- and P1-receptor blockers, functions and regulation by them; the characterization of these receptor signaling networks and crosstalk; mechanisms underlying the role of purinoceptors in neurodegenerative illnesses as well as chronic neuronal changes following acute noxious damage and therapeutic opportunities associated with regulation of purinergic receptor activity.