Nanoparticles in Ocular Drug Delivery Systems

• Other Authors: Almeida, Hugo (Editor), Silva, Ana Catarina (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Pharmaceutical industries; nanotechnology; fluorescence; ocular delivery; probes; diagnostics; PKs; cyclodextrin; ophthalmic; fosinopril sodium; niosomes; encapsulation; stabilization; flash nanoprecipitation; conjunctivitis; nanoparticles; zein; hyaluronic acid; ciprofloxacin; topical ocular drug delivery; transferosomes; linoleic acid; cyclosporine A; nanoparticle drug-delivery systems; retinal drug delivery; inner limiting membrane; photodisruption; vapor nanobubbles; indocyanine green; pulsed laser; tolnaftate; spanlastics; cosolvent; fungal keratitis; kill kinetics; susceptibility; cannabidiol; nanoemulsion; carbopol® 940 NF; autoclave; IOP; rabbits; corneal tissue engineering; epithelium; stroma; endothelium; 3D bioprinting; ocular diseases; sustained ocular delivery; therapeutic proteins; barriers of corneal tissues; nanocarriers; microcarriers; cell-penetrating peptides; hydrogels; ocular drug delivery; nebivolol; open-angle glaucoma; in situ gel; Box Behnken design; Poloxamer-407; kappa-carrageenan; glaucoma; chitosan; mucoadhesion; ocular bioavailability; therapeutic efficacy; triamcinolone acetonide; nanocrystals; ocular inflammation; corticosteroids; media milling; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic effi...