Chronic Kidney Disease: Underlying Molecular Mechanisms

• Other Authors: Carvalho, Márcia (Editor), Belo, Luís (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Pharmacology; kidney; lymphatics; sodium; NKCC1 transporter; CKD; inflammation; TNF-alpha; TNFR; biomarkers; chronic kidney disease; hypertension; children; short-chain fatty acids; developmental origins of health and disease (DOHaD); gut microbiota; probiotics; prebiotics; trimethylamine-N-oxide; oxidative stress; uremic toxins; TRPC6; UUO; NZO mice; fibrosis; SH045; heavy metals; cadmium; mercury; arsenic; cellular injury; urine proteome; FSGS; MCD; podocyte dysfunction; mass spectrometry; growth hormone; cachexia; lipolysis; adipose tissue browning; muscle mass; muscle function; skeletal muscle wasting; reactive oxygen species (ROS); exercise; Marinobufagenin (MBG); end-stage renal disease (ESRD); nervous and immune systems; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Chronic kidney disease (CKD) is a worldwide public health problem that must be addressed. The global increase in CKD prevalence is associated with an increase in conventional disease risk factors (e.g., diabetes and hypertension), which may be exacerbated by additional variables such as environmental and occupational exposure to toxic compounds. Authors contributed to this Special Issue by highlighting the finding of potential novel biomarkers of the disease and more effective therapy alternatives, as well as works that enhance the understanding of CKD pathogenesis and its related complications.