Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators

• Other Authors: Obrador, Elena (Editor), Montoro, Alegria (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Pharmacology; ferulic acid; total body irradiation; bone marrow microenvironment; stem cell senescence; bone marrow injury; reactive oxygen species; antioxidant defense system; planarians; model animal; irradiation; regeneration; radioprotection; radiation; melatonin; nDNA-repair; mtDNA-mutations; oxidation stress; protection; mitigation; H2O2; ATP; MDA; GSH; X-ray radiation; 3T3 fibroblasts; proliferation; apoptosis; cellular stress; senescence; peroxiredoxin 6; Prdx6; radioprotector; pharmacologic ascorbate; vitamin C; pancreatic cancer; Auranofin; thioredoxin; thioredoxin reductase; peroxiredoxin; nuclear and radiological emergencies; radioprotectors; radiomitigators; radionuclide scavengers; radiation biodosimetry; Olea europaea L. cv. Caiazzana; oleacein; ionising radiation; cancer; radiotherapy; normal tissue; radiosensitization; radiomodulation; proteomic analysis; oxidative modification profiling; serum albumin; amino acid sequences; radiation biomarker; human lactoferrin; acute gamma irradiation; C57Bl/6 mice; survival rate; open field test; spleen; serum homeostasis; leukocytes; stilbenoid; electron paramagnetic resonance (EPR); FT-IR; electron beam radiation; radioresistance; oxidative phosphorylation; oncometabolites; radiation response; bioinformatics; oxidative stress; transcriptomics; radiobiology database; gene signature; ionizing radiation; intestine; mucositis; microbiome; microbiota; dysbiosis; bacterial dietary supplement; radiomitigator; hyperthermia; combination therapy; synergistic effect; oxygenation; hypoxia; immune response; Tameron; antioxidant; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecu...