Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets

Chronic immune-mediated inflammatory diseases (IMIDs), usually accompanied by cardiovascular disease and neoplasias, are now prevailed worldwide. The limited efficacy of current therapeutics and a proportion of non-responders are linked to missing aspects in their pathophysiology at the molecular an...

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Other Authors: Christodoulou, Maria-Ioanna (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
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DOAB: description of the publication
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245 1 0 |a Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets 
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520 |a Chronic immune-mediated inflammatory diseases (IMIDs), usually accompanied by cardiovascular disease and neoplasias, are now prevailed worldwide. The limited efficacy of current therapeutics and a proportion of non-responders are linked to missing aspects in their pathophysiology at the molecular and cellular levels. High-throughput single- and multi-omics approaches and their combinations are expected to pinpoint the key players underlying IMIDs' establishment and/or progression, thus suggesting potential therapeutic targets and biomarkers. This Reprint gathered 13 papers presenting recent relevant data related to the assessment of CVD risk in RA, tailored therapeutics in RA-interstitial lung disease, IgG4-related RA, and Sjögren's syndrome, enabling early identification of PsA and improving outcomes in patients' with psoriasis. Also, novel non-invasive biomarkers for endoscopic activity and mucosal healing in ulcerative colitis, IBD, and cell-death-associated inflammatory syndromes are proposed. Moreover, a certain subset of telocytes is suggested as the pilot governor of epithelial behavior in preneoplastic gastric lesions, a newer member of IL-1 family, as it is a critical partner in lung adenocarcinoma, while distinct transcriptomic signatures and pathway profiles in human melanocytes corresponding to different Staphylococcal superantigenic enterotoxins are possible targets for therapeutic intervention in cases of toxic shocks. Lastly, Tregs- and dendritic cell-based IMID biomarkers are recommended to enable at more efficient, personalized, and precise treatment strategies. 
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653 |a rheumatoid 
653 |a immunoglobulin G 
653 |a immune system 
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653 |a periodontal disease 
653 |a cardiovascular disease 
653 |a biomarker 
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653 |a gelsolin 
653 |a mucosal healing 
653 |a interstitial lung disease 
653 |a biomarkers 
653 |a treatment 
653 |a superantigens 
653 |a gene expression 
653 |a transcriptional dynamics 
653 |a staphylococcal enterotoxins 
653 |a SEB 
653 |a SEA 
653 |a TSST-1 
653 |a toxins 
653 |a biological networks 
653 |a clustering 
653 |a functional pathways 
653 |a time-course analysis 
653 |a cDNA microarray 
653 |a human melanocytes 
653 |a cell death 
653 |a apoptosis 
653 |a necroptosis 
653 |a pyroptosis 
653 |a ubiquitin 
653 |a LUBAC 
653 |a OTULIN 
653 |a A20 
653 |a autoimmunity 
653 |a human genetics 
653 |a epigenetics 
653 |a endoscopy 
653 |a imaging 
653 |a laboratory testing 
653 |a Sjogren's syndrome 
653 |a patient stratification 
653 |a clinical relevance 
653 |a multi-omics 
653 |a psoriasis 
653 |a methylation 
653 |a histone 
653 |a ncRNAs 
653 |a immune-mediated inflammatory disorders 
653 |a autoimmune diseases 
653 |a immune regulation 
653 |a dendritic cells 
653 |a regulatory T cells 
653 |a omics 
653 |a therapeutic targeting 
653 |a chronic inflammation 
653 |a psoriatic diseases 
653 |a psoriatic arthritis 
653 |a data integration 
653 |a interleukin (IL-)37 
653 |a lung adenocarcinoma 
653 |a survival 
653 |a infiltration rates 
653 |a FoxL1+-telocytes 
653 |a epithelial-mesenchymal interaction 
653 |a BMP signaling 
653 |a extracellular matrix 
653 |a mechanical microenvironment 
653 |a matrisome 
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856 4 0 |a www.oapen.org  |u https://directory.doabooks.org/handle/20.500.12854/128698  |7 0  |z DOAB: description of the publication