Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets

• Other Authors: Christodoulou, Maria-Ioanna (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; arthritis; rheumatoid; immunoglobulin G; immune system; inflammation; proteins; proteomics; rheumatoid arthritis; periodontal disease; cardiovascular disease; biomarker; ulcerative colitis; gelsolin; mucosal healing; interstitial lung disease; biomarkers; treatment; superantigens; gene expression; transcriptional dynamics; staphylococcal enterotoxins; SEB; SEA; TSST-1; toxins; biological networks; clustering; functional pathways; time-course analysis; cDNA microarray; human melanocytes; cell death; apoptosis; necroptosis; pyroptosis; ubiquitin; LUBAC; OTULIN; A20; autoimmunity; human genetics; epigenetics; endoscopy; imaging; laboratory testing; Sjogren's syndrome; patient stratification; clinical relevance; multi-omics; psoriasis; methylation; histone; ncRNAs; immune-mediated inflammatory disorders; autoimmune diseases; immune regulation; dendritic cells; regulatory T cells; omics; therapeutic targeting; chronic inflammation; psoriatic diseases; psoriatic arthritis; data integration; interleukin (IL-)37; lung adenocarcinoma; survival; infiltration rates; FoxL1+-telocytes; epithelial-mesenchymal interaction; BMP signaling; extracellular matrix; mechanical microenvironment; matrisome
• Online Access: DOAB: download the publication; DOAB: description of the publication

Chronic immune-mediated inflammatory diseases (IMIDs), usually accompanied by cardiovascular disease and neoplasias, are now prevailed worldwide. The limited efficacy of current therapeutics and a proportion of non-responders are linked to missing aspects in their pathophysiology at the molecular an...