Current Insights on Lipid-Based Nanosystems 2023

• Other Authors: Silva, Ana Catarina (Editor), Moreira, João (Editor), Sousa Lobo, José Manuel (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Technology: general issues; design of experiment; porcine mucous membrane; ophthalmic tissues; permeation; nanostructured lipid carriers; gentiopicroside; phospholipid complex; self-nanoemulsion drug delivery system; oral bioavailability; pharmacokinetics; antioxidants; marine bio-waste; bioactive compounds; neurodegenerative diseases; NLC; solid lipid nanoparticles; SLN; intranasal administration; nose-to-brain; exosome; drug loading; exosomal delivery; large-scale production; lipid nanoparticles; mucoadhesion; ocular bioavailability; surface modification; liposomes; baricitinib; JAK-inhibitor; transepidermal delivery; skin permeation; lipid NPs; breast cancer; siRNA delivery; gene silencing; personalized therapy; bimatoprost; central composite design; glaucoma; HET-CAM test; solid lipid nanoparticles (SLNs); perillyl acid; biodistribution; empty lipid nanoparticles; reactogenicity; xenobiotics; ionizable lipids; isoniazid; in vivo pharmacokinetics; drug release profile; histopathological toxicity; mannosylation; nanocarriers; Chagas disease; Trypanosoma cruzi; in vivo assays; quality by design; plumbagin; diabetes; in vitro; niosomes; levosulpiride; antidepressant; acute toxicity; in vivo imaging; bioavailability; cisplatin; co-encapsulation; mifepristone; synergism; gefitinib; lipid; surfactant; stability; breast cancer cell; MTT assay; anticancer; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Lipid-based nanosystems, including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), cationic lipid nanoparticles, nanoemulsions, and liposomes, have been extensively studied to improve drug delivery through different administration routes. The main advantages linked to these systems are the ability to protect, transport, and control the release of lipophilic and hydrophilic molecules (either small molecular weight or macromolecules); the use of generally recognized as safe (GRAS) excipients that minimize the toxicity of the formulations; and the possibility to modulate pharmacokinetics and enable the site-specific delivery of encapsulated payloads. In addition, the versatility of lipid-based nanosystems has been further demonstrated through the delivery of vaccines, protection of cosmetic actives, or improvement in the moisturizing properties of cosmetic formulations. Currently, lipid-based nanosystems are well established, and there are already different commercially approved formulations for different human disorders. This success has actually paved the way to diversifying the pipeline of development, upon addressing unmet medical needs for several indications, such as cancer; neurological disorders; and autoimmune, genetic, and infectious diseases. This Special Issue aims to update readers on the latest research on lipid-based nanosystems, both at the preclinical and clinical levels.