Steroid Compounds with Potential Biological Activity

• Other Authors: Savić, Marina (Editor), Mernyák, Erzsébet (Editor), Ajdukovic, Jovana (Editor), Jovanović-Šanta, Suzana (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; 4-azasteroids; 4-azapregnenes; aldol condensation; molecular docking; antiproliferative activity; Paracaudina chilensis; Molpadida; triterpene glycosides; chilensosides; sea cucumber; cytotoxic activity; 26-thiodiosgenin; thiol oxidation; sulfoxides; sulfones; sapogenins; steroids; antimicrobial activity; cytotoxicity; breast cancer; endocrine therapy; endocrine resistance; aromatase inhibitors; exemestane; oxymestane; anti-cancer properties; multi-target compounds; aromatase; estrogen receptor; androgen receptor; Chan-Lam reaction; diaryl ether; 13α-estrone; antiproliferative effect; tubulin polymerization; molecular dynamics; oximes; chemistry; antitumor; anti-inflammatory; antibacterial; antifungal; antiviral; triterpenoids; isoprenoid lipids; anti-neoplastic; anti-fungal; anti-bacterial; anti-viral; fungal endophytes; plants; marine invertebrates; furanosteroids; fungi; marine organisms; diacetoxy-5α-cholestane; crystal structure HSA binding; multi-spectroscopy; DFT; steroid dimers; 1,4-phenylene-linked dimers; montmorillonite; DHEA; cholesterol; cation channels; TRPML1; bioisostere; estrogens; ring cleavage; protective groups; pyridines; pyrimidines; cyclization; antimetabolites; cell growth inhibition; gene expression; HeLa cells; in vitro culture
• Online Access: DOAB: download the publication; DOAB: description of the publication

Steroids are a large group of compounds whose structure is based on a 17-carbon skeleton, with a specific cyclopentanoperhydrophenanthrene ring system. Natural steroids have been fine-tuned through evolution to build membranes; act as chemical messengers that regulate metabolic, immune and reproduct...