Chapter 8 Research Strategies for Investigating Protein Ubiquitination in Lung Diseases

ch. 8 Post-translational modification (PTMs) determines protein's cellular functions including enzyme activity, localization, protein-protein interaction, and protein stability. Ubiquitin is a 7-kDa protein. Ubiquitination is one of PTMs and it is defined as protein covalently conjugation with...

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Autor principal: Zhao, Yutong (auth)
Formato: Recurso Electrónico Capítulo de Livro
Idioma:inglês
Publicado em: Taylor & Francis 2024
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Resumo:ch. 8 Post-translational modification (PTMs) determines protein's cellular functions including enzyme activity, localization, protein-protein interaction, and protein stability. Ubiquitin is a 7-kDa protein. Ubiquitination is one of PTMs and it is defined as protein covalently conjugation with a ubiquitin or poly-ubiquitin chains. A series of enzymatic reactions catalyze protein ubiquitination, which can be reversed by deubiquitinating enzymes (DUBs). The abnormal expression of ubiquitination-related enzymes and ubiquitination in lung cells have been demonstrated to alter cell functions, such as cell proliferation, death, and differentiation, ultimately contribute to the pathogenesis of lung diseases. In this chapter, we will introduce the methodology and research strategies for investigating protein ubiquitination in lung cells and experimental lung diseases. Common practice and edge-cutting laboratory technologies will be introduced in the chapter. Finally, we will discuss new drug development by targeting ubiquitination for therapies.
Descrição Física:1 electronic resource (13 p.)
ISBN:9781003355243-10
9781032409023
9781032409061
Acesso:Open Access