Chapter 8 Research Strategies for Investigating Protein Ubiquitination in Lung Diseases

ch. 8 Post-translational modification (PTMs) determines protein's cellular functions including enzyme activity, localization, protein-protein interaction, and protein stability. Ubiquitin is a 7-kDa protein. Ubiquitination is one of PTMs and it is defined as protein covalently conjugation with...

Full description

Saved in:
Bibliographic Details
Main Author: Zhao, Yutong (auth)
Format: Electronic Book Chapter
Language:English
Published: Taylor & Francis 2024
Subjects:
Online Access:DOAB: download the publication
DOAB: description of the publication
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000naaaa2200000uu 4500
001 doab_20_500_12854_132491
005 20240109
003 oapen
006 m o d
007 cr|mn|---annan
008 20240109s2024 xx |||||o ||| 0|eng d
020 |a 9781003355243-10 
020 |a 9781032409023 
020 |a 9781032409061 
040 |a oapen  |c oapen 
024 7 |a 10.1201/9781003355243-10  |c doi 
041 0 |a eng 
042 |a dc 
072 7 |a MJCM  |2 bicssc 
072 7 |a MJ  |2 bicssc 
072 7 |a PSD  |2 bicssc 
072 7 |a PSF  |2 bicssc 
072 7 |a PS  |2 bicssc 
100 1 |a Zhao, Yutong  |4 auth 
245 1 0 |a Chapter 8 Research Strategies for Investigating Protein Ubiquitination in Lung Diseases 
260 |b Taylor & Francis  |c 2024 
300 |a 1 electronic resource (13 p.) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a ch. 8 Post-translational modification (PTMs) determines protein's cellular functions including enzyme activity, localization, protein-protein interaction, and protein stability. Ubiquitin is a 7-kDa protein. Ubiquitination is one of PTMs and it is defined as protein covalently conjugation with a ubiquitin or poly-ubiquitin chains. A series of enzymatic reactions catalyze protein ubiquitination, which can be reversed by deubiquitinating enzymes (DUBs). The abnormal expression of ubiquitination-related enzymes and ubiquitination in lung cells have been demonstrated to alter cell functions, such as cell proliferation, death, and differentiation, ultimately contribute to the pathogenesis of lung diseases. In this chapter, we will introduce the methodology and research strategies for investigating protein ubiquitination in lung cells and experimental lung diseases. Common practice and edge-cutting laboratory technologies will be introduced in the chapter. Finally, we will discuss new drug development by targeting ubiquitination for therapies. 
536 |a Ohio State University Foundation 
540 |a Creative Commons  |f https://creativecommons.org/licenses/by-nc-nd/4.0/  |2 cc  |4 https://creativecommons.org/licenses/by-nc-nd/4.0/ 
546 |a English 
650 7 |a Immunology  |2 bicssc 
650 7 |a Clinical & internal medicine  |2 bicssc 
650 7 |a Molecular biology  |2 bicssc 
650 7 |a Cellular biology (cytology)  |2 bicssc 
650 7 |a Biology, life sciences  |2 bicssc 
653 |a asthma; cystic fibrosis; gas exchange; homeostasis; inflammation; lung diseas; lung endothelium;stem cells 
773 1 0 |7 nnaa  |o OAPEN Library UUID: Lung Biology and Pathophysiology 
856 4 0 |a www.oapen.org  |u https://library.oapen.org/bitstream/20.500.12657/86475/1/9781003355243_10.1201_9781003355243-10.pdf  |7 0  |z DOAB: download the publication 
856 4 0 |a www.oapen.org  |u https://directory.doabooks.org/handle/20.500.12854/132491  |7 0  |z DOAB: description of the publication