Chapter 7 Vitamin C in Pneumonia and Sepsis

In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by membe...

Full description

Saved in:
Bibliographic Details
Main Author: Carr, Anitra C. (auth)
Format: Electronic Book Chapter
Language:English
Published: Taylor & Francis 2020
Subjects:
Online Access:DOAB: download the publication
DOAB: description of the publication
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000naaaa2200000uu 4500
001 doab_20_500_12854_34828
005 20210210
003 oapen
006 m o d
007 cr|mn|---annan
008 20210210s2020 xx |||||o ||| 0|eng d
020 |a 9780429442025 
040 |a oapen  |c oapen 
041 0 |a eng 
042 |a dc 
072 7 |a MMG  |2 bicssc 
072 7 |a PSD  |2 bicssc 
072 7 |a PS  |2 bicssc 
100 1 |a Carr, Anitra C.  |4 auth 
245 1 0 |a Chapter 7 Vitamin C in Pneumonia and Sepsis 
260 |b Taylor & Francis  |c 2020 
300 |a 1 electronic resource (26 p.) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier. 
540 |a Creative Commons  |f https://creativecommons.org/licenses/by-nc-nd/4.0/  |2 cc  |4 https://creativecommons.org/licenses/by-nc-nd/4.0/ 
546 |a English 
650 7 |a Pharmacology  |2 bicssc 
650 7 |a Molecular biology  |2 bicssc 
650 7 |a Biology, life sciences  |2 bicssc 
653 |a antioxidants 
653 |a ascorbic acid 
653 |a infectious disease 
653 |a intravenous ascorbate 
773 1 0 |t Vitamin C  |7 nnaa  |o OAPEN Library UUID: 697ecf9a-49b3-44db-a92d-fe34d9723582 
856 4 0 |a www.oapen.org  |u https://library.oapen.org/bitstream/20.500.12657/40107/1/9781138337992_oachapter7.pdf  |7 0  |z DOAB: download the publication 
856 4 0 |a www.oapen.org  |u https://directory.doabooks.org/handle/20.500.12854/34828  |7 0  |z DOAB: description of the publication