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Chapter 15 Brain Tumors and the Lynch Syndrome

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Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is e...

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Bibliografski detalji
Glavni autor: Peltomäki, Päivi (auth)
Daljnji autori: Gylling, Annette (auth)
Format: Elektronički Poglavlje knjige
Jezik:engleski
Izdano: InTechOpen 2011
Teme:
Science: general issues
brain tumors
lynch syndrome
Colorectal cancer
DNA methylation
DNA mismatch repair
Gene
Glioblastoma
Glioma
Hereditary nonpolyposis colorectal cancer
Mutation
Neoplasm
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Opis
Sažetak:Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).
ISBN:21293
Pristup:Open Access

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