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Chapter 15 Brain Tumors and the Lynch Syndrome

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Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is e...

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Bibliografische gegevens
Hoofdauteur: Peltomäki, Päivi (auth)
Andere auteurs: Gylling, Annette (auth)
Formaat: Elektronisch Hoofdstuk
Taal:Engels
Gepubliceerd in: InTechOpen 2011
Onderwerpen:
Science: general issues
brain tumors
lynch syndrome
Colorectal cancer
DNA methylation
DNA mismatch repair
Gene
Glioblastoma
Glioma
Hereditary nonpolyposis colorectal cancer
Mutation
Neoplasm
Online toegang:DOAB: download the publication
DOAB: description of the publication
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Omschrijving
Samenvatting:Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).
ISBN:21293
Toegang:Open Access

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