Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2

• Main Author: Koller, Martin (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Biotechnology; Cupriavidus necator; alginate; tissue engineering; PAT; simulation; terpolyester; high cell density cultivation; process simulation; selective laser sintering; gaseous substrates; microaerophilic; in-line monitoring; Pseudomonas sp.; additive manufacturing; fed-batch; terpolymer; on-line; bubble column bioreactor; biopolymer; fused deposition modeling; biomaterials; polyhydroxyalkanoate (PHA); Pseudomonas putida; fed-batch fermentation; blends; upstream processing; wound healing; activated charcoal; downstream processing; Archaea; polyhydroxyalkanoates processing; film; bioreactor; medium-chain-length polyhydroxyalkanoate (mcl-PHA); poly(3-hydroxybutyrate-co-4-hydroxybutyrate); Ralstonia eutropha; hydrolysate detoxification; extremophiles; Poly(3-hydroxybutyrate); process analytical technologies; PHA composition; COMSOL; non-Newtonian fluid; tequila bagasse; biopolyester; biosurfactants; Haloferax; PHA; phenolic compounds; polyhydroxybutyrate; PHB; in-line; Pseudomonas; haloarchaea; plant oil; PHA processing; bioeconomy; delivery system; P(3HB-co-3HV-co-4HB); productivity; electrospinning; cyanobacteria; waste streams; polyhydroxyalkanoates; oxygen transfer; polyhydroxyalkanoate; biomedical application; photon density wave spectroscopy; carbon dioxide; salinity; PDW; rheology; halophiles; feedstocks; high-cell-density fed-batch; biomedicine; process engineering; bioprocess design; viscosity; computer-aided wet-spinning; microorganism; Cupriavidus malaysiensis; poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHVB)
• Online Access: DOAB: download the publication; DOAB: description of the publication

Nowadays, we are witnessing highly dynamic research activities related to the intriguing field of biodegradable materials with plastic-like properties. These activities are stimulated by the strengthened public awareness of prevailing ecological issues connected to growing piles of plastic waste and increasing greenhouse gas emissions; this goes hand-in-hand with the ongoing depletion of fossil feedstocks, which are traditionally used to produce full carbon backbone polymers. Polyhydroxyalkanoate (PHA) biopolyesters, a family of plastic-like materials with versatile material properties, are increasing considered to be a future-oriented solution for diminishing these concerns. PHA production is based on renewable resources and occurs in a bio-mediated fashion through the action of living organisms. If accomplished in an optimized way, PHA production and the entire PHA lifecycle are embedded into nature´s closed cycles of carbon. Sustainable and efficient PHA production requires understanding and improvement of all the individual process steps. Holistic improvement of PHA production, applicable on an industrially relevant scale, calls for, inter alia, consolidated knowledge about the enzymatic and genetic particularities of PHA-accumulating organisms, an in-depth understanding of the kinetics of the bioprocess, the selection of appropriate inexpensive fermentation feedstocks, tailoring of PHA composition at the level of its monomeric constituents, optimized biotechnological engineering, and novel strategies for PHA recovery from biomass characterized by low energy and chemical requirements. This Special Issue represents a comprehensive compilation of articles in which these individual aspects have been addressed by globally recognized experts.