Application of Antigen Cross-Presentation Research into Patient Care

• Autor principal: Marianne Boes (auth)
• Formato: Electrónico Capítulo de libro
• Lenguaje: inglés
• Publicado: Frontiers Media SA 2017
• Colección: Frontiers Research Topics
• Materias: Medicine; clinical translation; cross-presentation; Vaccination; Immunotherapy; dendritic cell
• Acceso en línea: DOAB: download the publication; DOAB: description of the publication

Sumario

The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view.

Descripción Física

1 electronic resource (124 p.)

ISBN

978-2-88945-191-3
9782889451913

Acceso

Open Access