Application of Antigen Cross-Presentation Research into Patient Care
The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate...
Saved in:
Main Author: | |
---|---|
Format: | Electronic Book Chapter |
Language: | English |
Published: |
Frontiers Media SA
2017
|
Series: | Frontiers Research Topics
|
Subjects: | |
Online Access: | DOAB: download the publication DOAB: description of the publication |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
LEADER | 00000naaaa2200000uu 4500 | ||
---|---|---|---|
001 | doab_20_500_12854_41040 | ||
005 | 20210211 | ||
003 | oapen | ||
006 | m o d | ||
007 | cr|mn|---annan | ||
008 | 20210211s2017 xx |||||o ||| 0|eng d | ||
020 | |a 978-2-88945-191-3 | ||
020 | |a 9782889451913 | ||
040 | |a oapen |c oapen | ||
024 | 7 | |a 10.3389/978-2-88945-191-3 |c doi | |
041 | 0 | |a eng | |
042 | |a dc | ||
072 | 7 | |a M |2 bicssc | |
100 | 1 | |a Marianne Boes |4 auth | |
245 | 1 | 0 | |a Application of Antigen Cross-Presentation Research into Patient Care |
260 | |b Frontiers Media SA |c 2017 | ||
300 | |a 1 electronic resource (124 p.) | ||
336 | |a text |b txt |2 rdacontent | ||
337 | |a computer |b c |2 rdamedia | ||
338 | |a online resource |b cr |2 rdacarrier | ||
490 | 1 | |a Frontiers Research Topics | |
506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
520 | |a The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
546 | |a English | ||
650 | 7 | |a Medicine |2 bicssc | |
653 | |a clinical translation | ||
653 | |a cross-presentation | ||
653 | |a Vaccination | ||
653 | |a Immunotherapy | ||
653 | |a dendritic cell | ||
856 | 4 | 0 | |a www.oapen.org |u http://journal.frontiersin.org/researchtopic/1985/application-of-antigen-cross-presentation-research-into-patient-care |7 0 |z DOAB: download the publication |
856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/41040 |7 0 |z DOAB: description of the publication |