Astrocytic-neuronal-astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA

Endocrinological research early recognized the importance of intercellular interactions and realized the importance of glutamatergic and GABAergic signaling. In turn this signalling depends on elaborate interactions between astrocytes and neurons, without which neurons would be unable to produce, re...

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Main Author: Tiago B. Rodrigues (auth)
Other Authors: Leif Hertz (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2014
Series:Frontiers Research Topics
Subjects:
Online Access:DOAB: download the publication
DOAB: description of the publication
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520 |a Endocrinological research early recognized the importance of intercellular interactions and realized the importance of glutamatergic and GABAergic signaling. In turn this signalling depends on elaborate interactions between astrocytes and neurons, without which neurons would be unable to produce, reuse and metabolize transmitter glutamate and GABA. Details of these subjects are described in this Research Topic by key investigators in this field. It focuses on the intricate and extremely swift pathway producing these amino acid transmitters from glucose in brain but also discusses difficulties in determining expression of some of the necessary genes in astrocytes and related processes in pancreatic islets. However, it does not discuss how closely associated astrocytes and neurons are anatomically, enabling these interactions. This is elegantly shown in this cover image, kindly provided by Professor Andreas Reichenbach (University of Leipzig, Germany). 
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653 |a Brain glutamine 
653 |a brain metabolism 
653 |a Appetite Regulation 
653 |a Astrocyte-oligdendrocyte interaction 
653 |a Brain ammonia 
653 |a GABA 
653 |a Astrocytic gene expression 
653 |a pancreatic islets 
653 |a Brain aspartate 
653 |a Brain glutamate 
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