Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges

• Main Author: Simone Fulda (auth)
• Other Authors: Thomas G. P. Grunewald (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Medicine; targeted therapy; Translational research; Ewing sarcoma; Sarcoma; pediatric oncology; Osteosarcoma; Immunotherapy; bone tumor; Rhabdomyosarcoma; epithelioid sarcoma
• Online Access: DOAB: download the publication; DOAB: description of the publication

Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of "omics" technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases...