Ca2+ Signaling and Heart Rhythm

• Main Author: Christopher L.-H. Huang (auth)
• Other Authors: Yunbo Ke (auth), R. John Solaro (auth), Ming Lei (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Physiology; Heart; Pak1; SA node; STIM1; TRPC; Ca2+; Orai1; PP2A; voltage gated Ca2+ channels
• Online Access: DOAB: download the publication; DOAB: description of the publication

Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regu...