Carbohydrates 2018
This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable a...
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Format: | Electronic Book Chapter |
Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2020
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Online Access: | DOAB: download the publication DOAB: description of the publication |
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100 | 1 | |a Rauter, Amélia Pilar |4 auth | |
700 | 1 | |a Xavier, Nuno Manuel |4 auth | |
245 | 1 | 0 | |a Carbohydrates 2018 |
260 | |b MDPI - Multidisciplinary Digital Publishing Institute |c 2020 | ||
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520 | |a This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer's disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research. | ||
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650 | 7 | |a Chemistry |2 bicssc | |
653 | |a chitosan | ||
653 | |a cancer treatment | ||
653 | |a n/a | ||
653 | |a theobromine | ||
653 | |a multivalent | ||
653 | |a carbohydrate | ||
653 | |a glycomimetic | ||
653 | |a capsular polysaccharide | ||
653 | |a isonucleosides | ||
653 | |a carbohydrate-based antitumor vaccines | ||
653 | |a carbohydrate antigen | ||
653 | |a sugars | ||
653 | |a Alzheimer's disease | ||
653 | |a conjugate vaccines | ||
653 | |a drug development | ||
653 | |a microparticles | ||
653 | |a cancer diagnosis | ||
653 | |a polyhydroxypiperidines | ||
653 | |a Streptococcus pneumoniae | ||
653 | |a iminosugar | ||
653 | |a oral films | ||
653 | |a Group B Streptococcus | ||
653 | |a C-glucosyl flavonoids | ||
653 | |a glycosidase inhibition | ||
653 | |a polyhydroxyazepanes | ||
653 | |a carbohydrate antigens | ||
653 | |a binding affinity | ||
653 | |a A?1-42 | ||
653 | |a glucosidase inhibition | ||
653 | |a lectin | ||
653 | |a Mitsunobu reaction | ||
653 | |a Microwave reactions | ||
653 | |a chromen-4-ones | ||
653 | |a iminosugars | ||
653 | |a flavones | ||
653 | |a cholinesterase inhibitors | ||
653 | |a chemoselective | ||
653 | |a glycoclusters | ||
653 | |a lead optimization | ||
653 | |a PAMPA | ||
653 | |a oxime | ||
653 | |a bioactive peptides | ||
653 | |a molecular modeling | ||
653 | |a buccal delivery | ||
653 | |a warburg effect | ||
653 | |a aminooxy | ||
653 | |a miglustat | ||
653 | |a miglitol | ||
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856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/42687 |7 0 |z DOAB: description of the publication |