Computational and Experimental Approaches in Multi-Target Pharmacology

• Auteur principal: Thomas J. Anastasio (auth)
• Format: Électronique Chapitre de livre
• Langue: anglais
• Publié: Frontiers Media SA 2017
• Collection: Frontiers Research Topics
• Sujets: Pharmacology; systems biology; computer modeling; drug repurposing; synergy; drug discovery; drug combination; high throughput screening; multidrug therapeutics; polypharmacy; multifactorial process
• Accès en ligne: DOAB: download the publication; DOAB: description of the publication

Résumé

The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics.

Description matérielle

1 electronic resource (122 p.)

ISBN

978-2-88945-252-1
9782889452521

Accès

Open Access