Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease

• Hoofdauteur: Iain P. Hargreaves (Ed.) (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: MDPI - Multidisciplinary Digital Publishing Institute 2018
• Onderwerpen: Medicine; biomarks; diagnosis; mitochondrial respiratory chain (MRC); mitochondrial disorders; biochemical parameters/markers; oxidative stress
• Online toegang: DOAB: download the publication; DOAB: description of the publication

Mitochondrial disease constitutes a complex and heterogeneous group of disorders resulting from a defect in mitochondrial respiratory chain (MRC) enzyme activity. In view of the dual regulation of the MRC, exercised by both the mitochondrial and nuclear genome, mutations in either mitochondrial or n...