Dendritic Cell Control of Immune Responses

Dendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissues and, upon activation, DC migrate to lymph nodes where they activate and educate T cells to initiate and shape the immune response. DC present pathogen-derived antigen to T cells and drive T cell di...

Full description

Saved in:
Bibliographic Details
Main Author: Lisa Helene Butterfield (auth)
Other Authors: Penelope Anne Morel (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2016
Series:Frontiers Research Topics
Subjects:
Online Access:DOAB: download the publication
DOAB: description of the publication
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000naaaa2200000uu 4500
001 doab_20_500_12854_44725
005 20210211
003 oapen
006 m o d
007 cr|mn|---annan
008 20210211s2016 xx |||||o ||| 0|eng d
020 |a 978-2-88919-868-9 
020 |a 9782889198689 
040 |a oapen  |c oapen 
024 7 |a 10.3389/978-2-88919-868-9  |c doi 
041 0 |a eng 
042 |a dc 
072 7 |a M  |2 bicssc 
100 1 |a Lisa Helene Butterfield  |4 auth 
700 1 |a Penelope Anne Morel  |4 auth 
245 1 0 |a Dendritic Cell Control of Immune Responses 
260 |b Frontiers Media SA  |c 2016 
300 |a 1 electronic resource (121 p.) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Frontiers Research Topics 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a Dendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissues and, upon activation, DC migrate to lymph nodes where they activate and educate T cells to initiate and shape the immune response. DC present pathogen-derived antigen to T cells and drive T cell differentiation into particular effector cells through the expression and secretion of co-stimulatory molecules and cytokines respectively. The study of DC biology has included the identification of multiple DC subsets in tissues and lymphoid organs, the differentiation and plasticity of DC subsets, the functional consequences of DC interaction with pathogen, control of DC migratory properties and the impact of DC on T cell activation and differentiation. In recent years sophisticated systems biology approaches have been developed to deepen our understanding of DC function. These studies have identified differences between DC subsets located in various tissues and critical factors that drive the outcome of the interaction between DC and T cells. DC are currently being used in in various clinical therapeutic settings, including as vaccines for cancer and autoimmune disease. A clear understanding of DC factors that contribute to specific immune responses is vital to the success of DC based therapies. This research topic will give a comprehensive overview of current issues in DC biology and provides an update on the clinical uses of DC in the therapy of autoimmunity and cancer. 
540 |a Creative Commons  |f https://creativecommons.org/licenses/by/4.0/  |2 cc  |4 https://creativecommons.org/licenses/by/4.0/ 
546 |a English 
650 7 |a Medicine  |2 bicssc 
653 |a Autoimmunity 
653 |a Dendritic Cells 
653 |a Immune Regulation 
653 |a T cells 
653 |a Cancer 
856 4 0 |a www.oapen.org  |u http://journal.frontiersin.org/researchtopic/1458/dendritic-cell-control-of-immune-responses  |7 0  |z DOAB: download the publication 
856 4 0 |a www.oapen.org  |u https://directory.doabooks.org/handle/20.500.12854/44725  |7 0  |z DOAB: description of the publication