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DNA Replication Controls

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The conditions for DNA replication are not ideal, owing to endogenous and exogenous replication stresses that lead to arrest of the replication fork. Arrested forks are among the most serious threats to genomic integrity because they can break or rearrange, leading to genomic instability, which is a...

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Bibliographic Details
Main Author: Eishi Noguchi (Ed.) (auth)
Format: Electronic Book Chapter
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2017
Subjects:
Biology, life sciences
DNA helicase
DNA replication
replication stress
replication checkpoint
DNA polymerase
telomere replication
cancer
genomic instability
DNA repair
replisome
translesion synthesis
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