Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome
This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirica...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , |
| Format: | Electronic Book Chapter |
| Language: | English |
| Published: |
Frontiers Media SA
2015
|
| Series: | Frontiers Research Topics
|
| Subjects: | |
| Online Access: | DOAB: download the publication DOAB: description of the publication |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry. |
|---|---|
| Physical Description: | 1 electronic resource (158 p.) |
| ISBN: | 978-2-88919-458-2 9782889194582 |
| Access: | Open Access |