The Evolution and Development of the Antibody Repertoire

• Main Author: Harry W Schroeder Jr (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; Antibody repertoire; immunoglobulin; B cells; sequence analysis software; comparative immunology; natural antibodies
• Online Access: DOAB: download the publication; DOAB: description of the publication

Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is...