Function and Flexibility: Friend or Foe?

• Main Author: Peter Tompa (auth)
• Other Authors: Kris Pauwels (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: conformational selection and induced fit; protein structure; conformational ensemble; Protein function; protein dynamics; Protein Conformation; protein flexibility; Protein Disorder; intrinsically disordered proteins; Structural transition
• Online Access: DOAB: download the publication; DOAB: description of the publication

Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that "form follows function". When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view...