Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches
This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The app...
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| Format: | Electronic Book Chapter |
| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2020
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| Online Access: | DOAB: download the publication DOAB: description of the publication |
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| 100 | 1 | |a Bermejo, Marival |4 auth | |
| 245 | 1 | 0 | |a Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches |
| 260 | |b MDPI - Multidisciplinary Digital Publishing Institute |c 2020 | ||
| 300 | |a 1 electronic resource (206 p.) | ||
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| 520 | |a This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro-in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by-nc-nd/4.0/ |2 cc |4 https://creativecommons.org/licenses/by-nc-nd/4.0/ | ||
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| 653 | |a model | ||
| 653 | |a polymer/clay composite | ||
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| 653 | |a bioequivalence | ||
| 653 | |a oral absorption | ||
| 653 | |a curcumin | ||
| 653 | |a P-gp | ||
| 653 | |a liquid-liquid phase separation | ||
| 653 | |a absorption | ||
| 653 | |a large bowel | ||
| 653 | |a dissolution | ||
| 653 | |a Ussing chamber | ||
| 653 | |a swelling | ||
| 653 | |a fimasartan | ||
| 653 | |a volume | ||
| 653 | |a dexketoprofen | ||
| 653 | |a gastrointestinal simulator | ||
| 653 | |a transit | ||
| 653 | |a controlled release formulations | ||
| 653 | |a experimental and computational permeability methods | ||
| 653 | |a magnetic resonance imaging | ||
| 653 | |a GastroPlus™ | ||
| 653 | |a in vitro-in vivo correlation (IVIVC) | ||
| 653 | |a diltiazem | ||
| 653 | |a MRI | ||
| 653 | |a gut | ||
| 653 | |a in vitro systems | ||
| 653 | |a CYP3A4 | ||
| 653 | |a poorly water-soluble drugs | ||
| 653 | |a regional absorption | ||
| 653 | |a intestinal permeability | ||
| 653 | |a butyric acid | ||
| 653 | |a intestinal drug absorption | ||
| 653 | |a gastrointestinal absorption | ||
| 653 | |a Biopharmaceutics Classification System (BCS) | ||
| 653 | |a anti-inflammatory | ||
| 653 | |a in vivo | ||
| 653 | |a colon microbiota | ||
| 653 | |a lipid-based formulations | ||
| 653 | |a in situ single-pass perfusion | ||
| 653 | |a metabolites | ||
| 653 | |a biorelevant media | ||
| 653 | |a fluconazole | ||
| 653 | |a colon delivery | ||
| 653 | |a modeling study | ||
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| 653 | |a motility | ||
| 653 | |a gellan gum | ||
| 653 | |a gastrointestinal drug release | ||
| 653 | |a large intestine | ||
| 653 | |a lipolysis | ||
| 653 | |a regional drug absorption | ||
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| 856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/48301 |7 0 |z DOAB: description of the publication |