Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches

• Main Author: Bermejo, Marival (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; in vitro dissolution; microscopy imaging; modulation; ionotropic gelation; laponite; biowaiver; beads; model; polymer/clay composite; flow; bioequivalence; oral absorption; curcumin; P-gp; liquid-liquid phase separation; absorption; large bowel; dissolution; Ussing chamber; swelling; fimasartan; volume; dexketoprofen; gastrointestinal simulator; transit; controlled release formulations; experimental and computational permeability methods; magnetic resonance imaging; GastroPlus™; in vitro-in vivo correlation (IVIVC); diltiazem; MRI; gut; in vitro systems; CYP3A4; poorly water-soluble drugs; regional absorption; intestinal permeability; butyric acid; intestinal drug absorption; gastrointestinal absorption; Biopharmaceutics Classification System (BCS); anti-inflammatory; in vivo; colon microbiota; lipid-based formulations; in situ single-pass perfusion; metabolites; biorelevant media; fluconazole; colon delivery; modeling study; mathematical modeling; motility; gellan gum; gastrointestinal drug release; large intestine; lipolysis; regional drug absorption
• Online Access: DOAB: download the publication; DOAB: description of the publication

This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The app...