Grappling with the Multifaceted World of the DNA Damage Response

• Main Author: Antonio Porro (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Genetics (non-medical); genome instability; DNA damage response; DNA Repair; Genome integrity; DNA Damage
• Online Access: DOAB: download the publication; DOAB: description of the publication

DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full doubl...