How aging affects T lymphocyte-mediated immunity

Increasing age has been associated with an insufficient protection following vaccination and an increased incidence and severity of infectious diseases. The predicted acceleration of global population aging will accentuate the need to understand the mechanisms that drive the age-related decline of t...

Full description

Saved in:
Bibliographic Details
Main Author: Dietmar Herndler-Brandstetter (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2015
Series:Frontiers Research Topics
Subjects:
Online Access:DOAB: download the publication
DOAB: description of the publication
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000naaaa2200000uu 4500
001 doab_20_500_12854_49586
005 20210211
003 oapen
006 m o d
007 cr|mn|---annan
008 20210211s2015 xx |||||o ||| 0|eng d
020 |a 978-2-88919-418-6 
020 |a 9782889194186 
040 |a oapen  |c oapen 
024 7 |a 10.3389/978-2-88919-418-6  |c doi 
041 0 |a eng 
042 |a dc 
072 7 |a M  |2 bicssc 
100 1 |a Dietmar Herndler-Brandstetter  |4 auth 
245 1 0 |a How aging affects T lymphocyte-mediated immunity 
260 |b Frontiers Media SA  |c 2015 
300 |a 1 electronic resource (77 p.) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Frontiers Research Topics 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a Increasing age has been associated with an insufficient protection following vaccination and an increased incidence and severity of infectious diseases. The predicted acceleration of global population aging will accentuate the need to understand the mechanisms that drive the age-related decline of the immune system and to, eventually, identify strategies to lower the burden of infectious diseases in elderly people. One type of immune cell appears to be most dramatically affected by the aging process: T lymphocytes. Age-related changes of the bone marrow and the thymus microenvironment lead to a decreased thymic output of functional, naïve T lymphocytes. As T lymphocytes are key players of the adaptive immune system, this research topic will summarize our current understanding on how aging affects the microenvironmental niches and molecular networks that are important for the generation, survival and function of naïve, memory and effector T lymphocytes. This research topic will also address the impact of aging on the different T lymphocyte lineages, such as regulatory T cells and Th17 cells and how age-related changes of the microenvironment affect organ- and tissue-resident memory T lymphocytes. Eventually, the identification of a set of markers for immunosenescence would facilitate the design and application of more specific therapies and improved vaccines and vaccination strategies for elderly people, thereby increasing life and health span. 
540 |a Creative Commons  |f https://creativecommons.org/licenses/by/4.0/  |2 cc  |4 https://creativecommons.org/licenses/by/4.0/ 
546 |a English 
650 7 |a Medicine  |2 bicssc 
653 |a Autoimmunity 
653 |a Cytomegalovirus 
653 |a Regulatory T Cell 
653 |a Vaccination 
653 |a Aging 
653 |a Influenza Virus 
653 |a biomarker 
653 |a health span 
856 4 0 |a www.oapen.org  |u http://journal.frontiersin.org/researchtopic/1133/how-aging-affects-t-lymphocyte-mediated-immunity  |7 0  |z DOAB: download the publication 
856 4 0 |a www.oapen.org  |u https://directory.doabooks.org/handle/20.500.12854/49586  |7 0  |z DOAB: description of the publication