The HSP70 Molecular Chaperone Machines

• Main Author: Matthias P. Mayer (auth)
• Other Authors: Pierre Goloubinoff (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Misfolding diseases; Heat-Shock Proteins; unfoldase; proteostasis; Disaggregase
• Online Access: DOAB: download the publication; DOAB: description of the publication

Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form HSPA1A (HSP70), its constitutive cytosolic cognate HSPA8 (Hsc70), its endoplasmic...