Hurdles for Phage Therapy (PT) to Become a Reality

• Autore principale: Brüssow, Harald (auth)
• Natura: Elettronico Capitolo di libro
• Lingua: inglese
• Pubblicazione: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Soggetti: Biology, life sciences; alginate; abortive infection; n/a; bacterial resistance; bacteriophages; ATMP; MALDI-MS; adaptation; Bacteriophage; horizontal gene transfer; adaptive immunity; co-evolution; Listeria ivanovii; personalised medicines; pH stability; phage-human host interaction; vB_SauM-fRuSau02; antimicrobial resistance; phagodisinfection; biofilm; capsule depolymerase; animal model; phage cocktails; Enterococcus; cases report; zoonosis; resistance; magistral formula; experimental therapy; Belgium; phage therapy; E. faecalis; nontraditional antibacterial; industrial phage application; Democratic Republic of the Congo; OrthoMCL; Germany; high-throughput sequencing; antimicrobial; infection; antibiotic therapy; Kayvirus; phages; Twortlikevirus; bacterial disease; human host; Pseudomonas aeruginosa; phage; multidrug-resistant bacteria; bacterial infection; Salmonella Typhi; rhamnopolysaccharide; compassionate use; crop production; compounding pharmacy; antimicrobial resistance (AMR); best practices; bacteriophage efficacy; phage sensitivity; antibiotic-resistance; antibiotic; lysins; PTMP; Escherichia coli; typhoid fever; patent landscape; phage preparation; innate immunity; anti-phage antibodies; immunology; Staphylococcus aureus; global health; clinical trial; adsorption; Brussels; phage-resistance; Galleria mellonella; science communication; history of science; virus-host interactions; foodborne illness; prophage; resistance management; biofilms; IND; immunomodulation; frequency of resistance; capsule; gastrointestinal tract; phage-host interactions; disinfection; production; bacteriophage therapy; bacteriophage; Staphylococcus; magistral preparation; extended-spectrum beta lactamases (ESBL); Viral proteins; antibiotic resistance; genomics; phage biocontrol; therapy; target selection; viral genomes; evolution; pharmaceutical paradigm shift; personalized medicine; pharmaceutical legislation; food safety; regulation; virulence; developing countries; infectious disease; regulatory framework; sustainable agriculture; Klebsiella pneumoniae
• Accesso online: DOAB: download the publication; DOAB: description of the publication

Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant...