Immune Checkpoint Molecules and Cancer Immunotherapy

• Main Author: Alexandr V. Bazhin (auth)
• Other Authors: Amedeo Amedei (auth), Svetlana Karakhanova (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2019
• Series: Frontiers Research Topics
• Subjects: Medicine; CTLA-4 (CD152); checkpoint blockade; Immunosuppression; cancer immunotherapy; PD-1 (CD279); Tumor Microenvironment; Metabolic checkpoints; immune checkpoint molecules; cytotoxic T lymphocytes; PDL1
• Online Access: DOAB: download the publication; DOAB: description of the publication

For the faultless function of the immune system, tight regulation of immune cell activation, immuno-suppression and the strength and efficiency of the immune response is essential. Immune checkpoint (ICP) molecules can amplify or dampen signals that lead to the modulation of specific immune activiti...