Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists

• Main Author: Michel Alexander Steiner (auth)
• Other Authors: Christopher J Winrow (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2014
• Series: Frontiers Research Topics
• Subjects: Neurology & clinical neurophysiology; Neuroscience; Addiction; hypocretin; Anxiety; orexin; orexin receptor antagonist; Neuropeptide; insomnia
• Online Access: DOAB: download the publication; DOAB: description of the publication

Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They b...