Ion Channel Trafficking and Cardiac Arrhythmias

• Main Author: Marcel A.G. van der Heyden (auth)
• Other Authors: Brian P. Delisle (auth), Hugues Abriel (auth), Baoxin Li (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Physiology; Kv11.1 channels; Connexin43 (Cx43); ion channel; arrhythmia; TRPM4 channel; Glycosylation; NaV1.5 channels; Kir2.1 channels; trafficking; Autophagy; Protein complexes
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

A well-adjusted expression of cardiac ion channels at the sarcolemma is of crucial importance for normal action potential formation and thus cardiac function. The cellular processes that transport channel proteins from the endoplasmic reticulum towards specified regions on the sarcolemmal membrane, and subsequently take them from the plasma membrane to the protein degradation machinery are commonly known as trafficking. The research field recognizes that aberrant channel trafficking stands at the basis of many congenital and acquired arrhythmias. The collection of papers in this eBook provides state-of-the-art insight into the world of ion channel trafficking research.

Physical Description

1 electronic resource (123 p.)

ISBN

978-2-88945-643-7
9782889456437

Access

Open Access