Ion Channel Trafficking and Cardiac Arrhythmias

• Main Author: Marcel A.G. van der Heyden (auth)
• Other Authors: Brian P. Delisle (auth), Hugues Abriel (auth), Baoxin Li (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Physiology; Kv11.1 channels; Connexin43 (Cx43); ion channel; arrhythmia; TRPM4 channel; Glycosylation; NaV1.5 channels; Kir2.1 channels; trafficking; Autophagy; Protein complexes
• Online Access: DOAB: download the publication; DOAB: description of the publication

A well-adjusted expression of cardiac ion channels at the sarcolemma is of crucial importance for normal action potential formation and thus cardiac function. The cellular processes that transport channel proteins from the endoplasmic reticulum towards specified regions on the sarcolemmal membrane,...