Iron as Therapeutic Targets in Human Diseases Volume 2

Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the...

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Bibliographic Details
Main Author:	Gozzelino, Raffaella (auth)
Other Authors:	Poli, Maura (auth), Arosio, Paolo (auth)
Format:	Electronic Book Chapter
Language:	English
Published:	MDPI - Multidisciplinary Digital Publishing Institute 2020
Subjects:	Biology, life sciences developmental Anemia of chronic disease neurodegeneration supplementation MHC iron chelation therapy osteoblast serum biomarker FeSO4 haptoglobin prevention brain development pituitary trauma hepcidin Alzheimer's disease chaotropes social behavior Africa macrophage anemia of inflammation Tfr2 chelation cardiomyocyte IV iron therapy Oxidative stress treatment chronic kidney disease iron homeostasis oxygen sensing iron chelators age-related macular degeneration (AMD) pharmaceutical targets non-transferrin-bound iron (NTBI) iron dextran pulmonary arterial hypertension labile iron low and middle income countries ferroportin gut microbiota reducibility non-HFE oxidative stress antitumor compound senescence electron transfer nanotechnology iron deficiency neonatal period heme oxygenase hypoxia Anemia NCOA4 patient blood management microbiome anemia iron mobilization iron release phlebotomy peritoneal dialysis Friedreich Ataxia ferritin CD8+ T cells M cells neurodegenerative disease NaFeEDTA vascular calcification cinnamic acid derivatives oral iron salts lipid acute lung injury Iron-sulfur Interleukin-6 neurodegeneration with brain iron accumulation macrophages erythroblastic islands cystic fibrosis neuroimmune responses flavin nucleotide hemopexin Iron chelators nutrient iron developing countries hereditary hypoferritinemia iron cancer Indonesia n/a Hfe HFE chronic heart failure iron supplementation intestinal inflammation TNF chelators hemolysis children pulmonary arterial smooth muscle cells cytokines didox intravenous iron T lymphocytes colorectal cancer infants liver ferritinophagy hereditary hyperferritinemia SCFA rheumatoid arthritis membrane interactions Sucrosomial® iron lung Kupffer cell iron chelation erythrophagocytosis acute kidney injury neurophysiology iron transporters iron absorption infection ferroptosis fluorescent iron chelator neonatal SNC immunity mycobacteria non-haem iron natural history 3-hydroxy-4-pyridinone haem inflammation bone homeostasis cardiovascular disease heme heme homeostasis protein binding brain iron deficiency anemia Fe2+-chelating activity bioengineering Mek/Erk Bmp/Smad iron delivery genetic hemochromatosis osteoclast histidine rhodamine COPD hemorrhage antibacterial activity bacteria SLC40A1 transferrin receptor drug delivery nanocage soybean seed ferritin pig iron metabolism kidney innate immunity cataracts syndrome erythropoiesis obesity mucosal immunity iron overload fluorophore binding ability inflammatory bowel disease (IBD) osteoporosis biomarker bioavailability adverse event profile metabolism iron-carbohydrate complex kinetics flavonoids iron regulatory proteins lung infection non transferrin bound iron central nurse macrophage iron processing malaria neurodegenerative diseases multifunctional iron chelators retina neuroinflammation anti-hepcidin therapy lung diseases anaemia RRM2 cognition mitochondria therapy NBIA red pulp macrophage efficacy hemochromatosis tolerability oral iron therapy growth venesections
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