The Ischemic Penumbra: Still the Target for Stroke Therapies?

• Main Author: Argye E. Hillis (auth)
• Other Authors: Jean-Claude Baron (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; Diffusion-weighted imaging; penumbra; Magnetic Resonance Imaging; cerebrovascular disease; Acute ischemic stroke; perfusion-weighted imaging; regional cerebral blood flow; positron emission tomography; Computer Tomography Perfusion
• Online Access: DOAB: download the publication; DOAB: description of the publication

The ischemic penumbra was initially defined by Symon, Lassen and colleagues in the 1970s as an area of brain tissue with inadequate blood flow to maintain electric activity of neurons but adequate blood flow to preserve the function of the ion channels. This area of tissue, receiving enough blood to...