Self-Assembled Molecules - New Kind of Protein Ligands: Supramolecular Ligands

• Hoofdauteur: Irena Roterman (auth)
• Andere auteurs: Leszek Konieczny (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: Springer Nature 2017
• Onderwerpen: Biochemistry; ligands; congo red amyloids; immunotargeting techniques; intramolecular immunological signals
• Online toegang: DOAB: download the publication; DOAB: description of the publication

The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but "naturally irreversible" complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book.