Major Histocompatibility Complex (MHC) in Health and Disease

• Main Author: Shiina, Takashi (auth)
• Other Authors: Dijkstra, Johannes M. (auth), Kulski, Jerzy K. (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Biology, life sciences; HCP5; n/a; camels; MHC; STK19; major histocompatibility complex; human papillomavirus (HPV); T-cell receptor; T1DGC; bottleneck; micro-mini-pigs; life history; computational analysis; hepatocellular carcinoma; phase; Bactrian camel; NSDK; melanoma; antigen; autoimmune disease; RD; selection; disease resistance; autoimmunity; ancestral haplotype; Ski complex; DXO; high-throughput sequencing; conservation genetics; SVA; lncRNA; ankylosing spondylitis; MHC genes; viral peptides; competing endogenous RNA (ceRNA); astrogliosis; birds; long-fragment super haplotype; SNP; RLR; HLA polymorphism; 5??3? RNA decay; expression; 3??5? mRNA turnover; orthology; long-read sequencing; disease association; dromedary; polyomavirus; MHC-II-associated sperm-egg recognition; experimental medicine; single nucleotide polymorphism (SNP); fish; SKIV2L; production trait; molecular dynamics simulation; Macaca fascicularis; human endogenous retrovirus (HERV); concerted evolution; polymorphism; Old World camels; MHC polymorphism; protocol; nonclassical; gene duplication; microglial reaction; human leukocyte antigen-E; SKI2W; quantitative trait loci (QTL) studies; antiviral immunity; human immunodeficiency virus (HIV); founder effect; giant panda; domain movements; BK virus; promoter-proximal transcriptional pause; type 1 diabetes (T1D); RP1; miR1236; KIR; synaptic covering; swine leukocyte antigen; cynomolgus macaque; HLA; kidney transplantation; ?2m knockout mice; DOM3Z; interferon ?; ethnic populations in China; ecology; KIR-HLA pairs; exosomes; major histocompatibility complex (MHC); MHC-I-based mother-fetus recognition; RNA quality control; autoimmune diseases; NELF-E; haplotype; genetic drift; evolution; nonhuman primate models; HLA-B27; PNS/CNS interface; risk genes; pedigree; MHC-I- and MHC-II-dependent inter-individual recognition; regulation; crested ibis; reproductive performance; nephropathy; cancer; nuclear kinase; trichohepatoenteric syndrome
• Online Access: DOAB: download the publication; DOAB: description of the publication

The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually...