Mesothelial Physiology and Pathophysiology
The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides prov...
Saved in:
Main Author: | |
---|---|
Format: | Electronic Book Chapter |
Language: | English |
Published: |
Frontiers Media SA
2018
|
Series: | Frontiers Research Topics
|
Subjects: | |
Online Access: | DOAB: download the publication DOAB: description of the publication |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
LEADER | 00000naaaa2200000uu 4500 | ||
---|---|---|---|
001 | doab_20_500_12854_53210 | ||
005 | 20210211 | ||
003 | oapen | ||
006 | m o d | ||
007 | cr|mn|---annan | ||
008 | 20210211s2018 xx |||||o ||| 0|eng d | ||
020 | |a 978-2-88945-541-6 | ||
020 | |a 9782889455416 | ||
040 | |a oapen |c oapen | ||
024 | 7 | |a 10.3389/978-2-88945-541-6 |c doi | |
041 | 0 | |a eng | |
042 | |a dc | ||
072 | 7 | |a MFG |2 bicssc | |
100 | 1 | |a Sotirios G. Zarogiannis |4 auth | |
245 | 1 | 0 | |a Mesothelial Physiology and Pathophysiology |
260 | |b Frontiers Media SA |c 2018 | ||
300 | |a 1 electronic resource (81 p.) | ||
336 | |a text |b txt |2 rdacontent | ||
337 | |a computer |b c |2 rdamedia | ||
338 | |a online resource |b cr |2 rdacarrier | ||
490 | 1 | |a Frontiers Research Topics | |
506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
520 | |a The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides providing a slippery surface for the frictionless movement of internal organs, the mesothelium participates in a wide range of physiological and pathophysiological processes. Some of its functions include lung development, trans-cellular and para-cellular transport of ions and water, secretion of glycoproteins (mainly hyaluronan), secretion of cytokines and growth factors, wound healing, response to inflammatory stimuli and induction of inflammation, mesothelial to mesenchymal transition and formation of tunneling nanotubes. Many of these functions are pivotal to physiological conditions such as respiratory development, maintenance of steady volume of serosal fluids and serosal permeability, cell-to-cell communication, re-mesotheliazation of serosal membranes after mechanical (e.g. by asbestos or nanoparticles) or inflammatory injury and participation in immune responses. Deviation from the physiological threshold of these functions results in the development of serosal effusions, induction of serosal and lung fibrosis, induction of mesothelial tumorigenesis, leading thus to devastating pathologies. Treatment of pathologies like mesothelioma, pleural and peritoneal fibrosis (in cases of patients under Peritoneal Dialysis) or lung fibrosis still pose a great challenge for researchers. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
546 | |a English | ||
650 | 7 | |a Physiology |2 bicssc | |
653 | |a Mesothelium | ||
653 | |a Serosal Membranes | ||
653 | |a Physiology | ||
653 | |a Pleura | ||
653 | |a Peritoneum | ||
653 | |a Pericardium | ||
856 | 4 | 0 | |a www.oapen.org |u https://www.frontiersin.org/research-topics/2153/mesothelial-physiology-and-pathophysiology |7 0 |z DOAB: download the publication |
856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/53210 |7 0 |z DOAB: description of the publication |