Metabolomics in Neurodegenerative Disease

• Main Author: Green, Brian (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Biology, life sciences; glutamic acid; n/a; direct mass spectrometry; neurodegeneration; 6-OHDA; targeted mass spectrometry; mitochondrial dysfunction; myo-inositol; metabolomics; bile acids; subacute mild traumatic brain injury; age-related macular degeneration; metabolic pathways; energy metabolism; midbrain; Alzheimer's disease; biomarkers; 1H NMR; Parkinson's disease dementia; GC-MS; pathogenesis; tricarboxylic acid cycle; micro-dialysis; 13C-labeled succinate; metabolism; lipidomics; dementia with Lewy bodies; fatty acid; prodromal Parkinson's disease; malonate; cerebral ischemia; mass spectrometry; retinal pigment epithelium; excitotoxicity; endothelin-1; reperfusion; C. elegans; Streptomyces venezuelae; ?-synuclein aggregates; natural product; fatty acid metabolism; imaging mass spectrometry; LC-MS; drusen; cerebral palsy; plasma; Parkinson's disease
• Online Access: DOAB: download the publication; DOAB: description of the publication

The range of human neurodegenerative diseases continues to pose significant unmet medical needs for societies around the world. The progressive and terminal nature of these conditions places a considerable personal burden on the individual affected but also on public health systems and health servic...