Methods in Computational Biology

• Main Author: Carlson, Ross (auth)
• Other Authors: Sauro, Herbert (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Information technology industries; n/a; inosine; immune checkpoint inhibitor; geometric singular perturbation theory; simulation; BioModels Database; ADAR; calcium current; bifurcation analysis; bacterial biofilms; nonlinear dynamics; explanatory model; turning point bifurcation; oscillator; workflow; bioreactor integrated modeling; modeling methods; elementary flux modes visualization; multiscale systems biology; evolutionary algorithm; metabolic model; differential evolution; reduced-order model; computational model; gut microbiota dysbiosis; canard-induced EADs; computational biology; metabolic modelling; methods; SREBP-2; mechanistic model; systems modeling; biological networks; macromolecular composition; provenance; flux balance analysis; immunotherapy; compartmental modeling; immuno-oncology; metabolic network visualization; mechanism; bistable switch; Clostridium difficile infection; bioreactor operation optimization; microRNA targeting; CFD simulation; biomass reaction; RNA editing; ordinary differential equation; metabolic modeling; mass-action networks; hybrid model; multiple time scales; quantitative systems pharmacology (QSP); mathematical modeling; microRNA; cancer; parameter optimization; Hopf bifurcation; breast
• Online Access: DOAB: download the publication; DOAB: description of the publication

Modern biology is rapidly becoming a study of large sets of data. Understanding these data sets is a major challenge for most life sciences, including the medical, environmental, and bioprocess fields. Computational biology approaches are essential for leveraging this ongoing revolution in omics dat...