Molecular mechanisms regulating cytotoxic lymphocyte development and function, and their associations to human diseases

• Main Author: Konrad Krzewski (auth)
• Other Authors: Yenan Bryceson (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; secretory lysosomes; NK cells; hemophagocytic histiocytosis; immune therapy; granzyme; lytic granules; Cytotoxicity; anti-tumor response; Immunological Synapse; Perforin
• Online Access: DOAB: download the publication; DOAB: description of the publication

Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and che...