Monitoring endogenous GPCRs: lessons for drug design

• Main Author: Dominique Massotte (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Pharmacology; opioid receptors; G protein coupled receptors; CGamP mice; FLIM; fluorescent knock-in mice; receptor heteromerization; Endogenous receptors; cannabinoid receptors; biased signaling; Opiate tolerance
• Online Access: DOAB: download the publication; DOAB: description of the publication

G protein-coupled receptors (GPCRs) are integral membrane proteins forming the fourth largest superfamily in the human genome. Many of these receptors play key physiological roles and several pathologies have been associated with receptor functional abnormalities. GPCRs therefore represent important...