Neural Circuitry of Behavioral Flexibility: Dopamine and Related Systems

• Main Author: Matthew R. Roesch (auth)
• Other Authors: Gregory B. Bissonette (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Neurosciences; behavioral flexibility; Dopamine; medial prefrontal cortex (mPFC); Attentional set-shifting; basal forebrain; anterior cingulate cortex (ACC); endocannabinoid system; lateral habenula (LHb); Locus coeruleus (LC); motivational salience
• Online Access: DOAB: download the publication; DOAB: description of the publication

Decades of research have identified a role for dopamine neurotransmission in prefrontal cortical function and flexible cognition. Abnormal dopamine neurotransmission underlies many cases of cognitive dysfunction. New techniques using optogenetics have allowed for ever more precise functional segrega...